Gene

myrf

ID

ZDB-GENE-080204-57

Name

myelin regulatory factor

Symbol

myrf Nomenclature History

Previous Names

c11orf9 (1)
zgc:172183

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription, DNA-templated. Predicted to localize to cytoplasm and nucleus. Orthologous to human MYRF (myelin regulatory factor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 8 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With myrf Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Cardiac-urogenital syndrome	618280
		Encephalitis/encephalopathy, mild, with reversible myelin vacuolization	618113

Associated With myrf Via Experimental Models

Human Disease	Fish	Conditions	Citations
eye disease	AB + MO1-myrf	standard conditions	Xiao et al., 2019

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR024061	NDT80 DNA-binding domain
Domain	IPR025719	Myelin gene regulatory factor C-terminal domain 2
Domain	IPR026932	Myelin gene regulatory factor, ICA domain
Domain	IPR030392	Intramolecular chaperone auto-processing domain
Homologous_superfamily	IPR008967	p53-like transcription factor, DNA-binding domain superfamily
Homologous_superfamily	IPR037141	NDT80 DNA-binding domain superfamily

Domain Details Per Protein

Protein	Length	Intramolecular chaperone auto-processing domain	Myelin gene regulatory factor C-terminal domain 2	Myelin gene regulatory factor, ICA domain	NDT80 DNA-binding domain	NDT80 DNA-binding domain superfamily	p53-like transcription factor, DNA-binding domain superfamily
UniProtKB:A0A8M3ANV6 InterPro	1027
UniProtKB:A0A8M9P6L9 InterPro	1009
UniProtKB:A0A8M9PV81 InterPro	1034
UniProtKB:A0A8M9PYN2 InterPro	1036
UniProtKB:A0A8M3AWA7 InterPro	1037
UniProtKB:A0A8M9PH29 InterPro	1008

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	myrf-201 (1) Ensembl	Havana	4844 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	myrf-202 (1) Ensembl	Havana	2051 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations