Gene

chata

ID

ZDB-GENE-080102-2

Name

choline O-acetyltransferase a

Symbol

chata Nomenclature History

Previous Names

baj
chat
unm tk64
unm_tk64

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to have choline O-acetyltransferase activity. Involved in locomotory behavior. Predicted to localize to cytoplasm and neuron projection. Used to study congenital myasthenic syndrome. Human ortholog(s) of this gene implicated in Alzheimer's disease and congenital myasthenic syndrome 6. Is expressed in brain; neurons; post-vent region; and spinal cord. Orthologous to human CHAT (choline O-acetyltransferase).

Genome Resources

Note

Yokogawa et al. (2007) identified the chat gene with Ensembl ENSDARG00000015854 on Chr. 13.

Comparative Information

Expression

All Expression Data

24 figures from 16 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 13 figures from 5 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With chata Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
congenital myasthenic syndrome 6	Alliance	Myasthenic syndrome, congenital, 6, presynaptic	254210

Associated With chata Via Experimental Models

Human Disease	Fish	Conditions	Citations
congenital myasthenic syndrome	chata^tk64/tk64 (AB)	standard conditions	Joshi et al., 2018

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR039551	Choline/carnitine acyltransferase domain
Family	IPR000542	Acyltransferase ChoActase/COT/CPT
Homologous_superfamily	IPR023213	Chloramphenicol acetyltransferase-like domain superfamily
Homologous_superfamily	IPR042231	Choline/Carnitine o-acyltransferase, domain 2