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General Information
ZIRC
ZFIN ID: ZDB-GENE-071218-6
Gene Name: leucine-rich repeat kinase 2
Gene Symbol: lrrk2
GO Details
Ontology Qualifier Term Evidence Inferred From Annotation Extension Reference(s)
Molecular Function ATP binding IEA InterPro:IPR000719 ZFIN Electronic Annotation
ATP binding IEA InterPro:IPR017441 ZFIN Electronic Annotation
kinase activity IEA UniProtKB-KW:KW-0418 ZFIN Electronic Annotation
protein kinase activity IEA InterPro:IPR000719 ZFIN Electronic Annotation
protein kinase activity IEA InterPro:IPR008271 ZFIN Electronic Annotation
protein serine/threonine kinase activity IBA PANTHER:PTN002356424 Gaudet et al., 2010
Rho GTPase binding IBA PANTHER:PTN001147480 Gaudet et al., 2010
transferase activity IEA UniProtKB-KW:KW-0808 ZFIN Electronic Annotation
volume-sensitive anion channel activity IBA PANTHER:PTN001140629 Gaudet et al., 2010
Cellular Component cytoplasm IBA PANTHER:PTN001140629 Gaudet et al., 2010
cytosol IBA PANTHER:PTN001147480 Gaudet et al., 2010
endoplasmic reticulum IBA PANTHER:PTN001147480 Gaudet et al., 2010
endosome IBA PANTHER:PTN001147480 Gaudet et al., 2010
Golgi apparatus IBA PANTHER:PTN001147480 Gaudet et al., 2010
ion channel complex IBA PANTHER:PTN001140629 Gaudet et al., 2010
lysosome IBA PANTHER:PTN001147480 Gaudet et al., 2010
membrane raft IBA PANTHER:PTN001147480 Gaudet et al., 2010
mitochondrial membrane IBA PANTHER:PTN001147480 Gaudet et al., 2010
neuron projection IBA PANTHER:PTN001147480 Gaudet et al., 2010
plasma membrane IBA PANTHER:PTN001147480 Gaudet et al., 2010
Biological Process calcium-mediated signaling IBA PANTHER:PTN001147480 Gaudet et al., 2010
mitochondrion organization IBA PANTHER:PTN001147480 Gaudet et al., 2010
negative regulation of autophagosome assembly IBA PANTHER:PTN001147480 Gaudet et al., 2010
phosphorylation IEA UniProtKB-KW:KW-0418 ZFIN Electronic Annotation
protein phosphorylation IEA InterPro:IPR000719 ZFIN Electronic Annotation
protein phosphorylation IEA InterPro:IPR008271 ZFIN Electronic Annotation
regulation of dendritic spine morphogenesis IBA PANTHER:PTN001147480 Gaudet et al., 2010
regulation of retrograde transport, endosome to Golgi IBA PANTHER:PTN001147480 Gaudet et al., 2010
regulation of synaptic vesicle transport IBA PANTHER:PTN001147480 Gaudet et al., 2010