Gene

arhgef11

ID

ZDB-GENE-070604-1

Name

Rho guanine nucleotide exchange factor (GEF) 11

Symbol

arhgef11 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Exhibits G-protein alpha-subunit binding activity. Involved in several processes, including epithelial cilium movement involved in extracellular fluid movement; otolith development; and stress fiber assembly. Predicted to localize to cytoplasm. Is expressed in central nervous system; head; and pronephric duct. Orthologous to human ARHGEF11 (Rho guanine nucleotide exchange factor 11).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from Panizzi et al., 2007

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from Panizzi et al., 2007
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With arhgef11 Human Ortholog

No data available

Associated With arhgef11 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR001331	Guanine-nucleotide dissociation stimulator, CDC24, conserved site
Domain	IPR000219	Dbl homology (DH) domain
Domain	IPR001478	PDZ domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR015212	Regulator of G protein signalling-like domain
Domain	IPR037889	Rho guanine nucleotide exchange factor 11, RGS domain
Domain	IPR041020	ARHGEF1-like, PH domain
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR035899	Dbl homology (DH) domain superfamily
Homologous_superfamily	IPR036034	PDZ superfamily
Homologous_superfamily	IPR036305	RGS domain superfamily
Homologous_superfamily	IPR044926	RGS, subdomain 2

Domain Details Per Protein

Protein	Length	ARHGEF1-like, PH domain	Dbl homology (DH) domain	Dbl homology (DH) domain superfamily	Guanine-nucleotide dissociation stimulator, CDC24, conserved site	PDZ domain	PDZ superfamily	PH-like domain superfamily	Pleckstrin homology domain	Regulator of G protein signalling-like domain	RGS domain superfamily	RGS, subdomain 2	Rho guanine nucleotide exchange factor 11, RGS domain
UniProtKB:Q49U75 InterPro	1417

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	arhgef11-201 (1) Ensembl	Havana	2252 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	arhgef11-202 (1) Ensembl	Havana	521 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	arhgef11-203 (1) Ensembl	Havana	5755 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations