Gene

usp9

ID

ZDB-GENE-061019-1

Name

ubiquitin specific peptidase 9

Symbol

usp9 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to have cysteine-type endopeptidase activity and thiol-dependent ubiquitin-specific protease activity. Predicted to be involved in cell migration and protein deubiquitination. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in Y-linked spermatogenic failure 2 and non-syndromic X-linked intellectual disability. Is expressed in endodermal cell; myotome; nervous system; pectoral fin; and solid lens vesicle. Orthologous to several human genes including USP9X (ubiquitin specific peptidase 9 X-linked).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Khut et al., 2007

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Köglsberger et al., 2017
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With usp9 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
female-restricted syndromic X-linked intellectual disability 99	Alliance	Intellectual developmental disorder, X-linked 99, syndromic, female-restricted	300968
non-syndromic X-linked intellectual disability 99	Alliance	Intellectual developmental disorder, X-linked 99	300919
Y-linked spermatogenic failure 2	Alliance	Spermatogenic failure, Y-linked, 2	415000

Associated With usp9 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018200	Ubiquitin specific protease, conserved site
Domain	IPR001394	Peptidase C19, ubiquitin carboxyl-terminal hydrolase
Domain	IPR021905	Ubiquitin C-terminal hydrolase-like, DUF3517
Domain	IPR028889	Ubiquitin specific protease domain
Homologous_superfamily	IPR016024	Armadillo-type fold
Homologous_superfamily	IPR038765	Papain-like cysteine peptidase superfamily

Domain Details Per Protein

Protein	Length	Armadillo-type fold	Papain-like cysteine peptidase superfamily	Peptidase C19, ubiquitin carboxyl-terminal hydrolase	Ubiquitin C-terminal hydrolase-like, DUF3517	Ubiquitin specific protease, conserved site	Ubiquitin specific protease domain
UniProtKB:Q4FE55 InterPro	2551
UniProtKB:A0A8M3AW48 InterPro	2557
UniProtKB:A0A8M3B5Q3 InterPro	2593
UniProtKB:A0A8M3B2R0 InterPro	2558
UniProtKB:A0A8M2BF50 InterPro	2594