Gene
dot1l
- ID
- ZDB-GENE-060503-341
- Name
- DOT1-like histone H3K79 methyltransferase
- Symbol
- dot1l Nomenclature History
- Previous Names
-
- si:dkey-211f22.1
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to have histone methyltransferase activity (H3-K79 specific). Involved in canonical Wnt signaling pathway; cellular homeostasis; and intestinal epithelial structure maintenance. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in mixed phenotype acute leukemia. Is expressed in hindbrain; intestine; and midbrain. Orthologous to human DOT1L (DOT1 like histone lysine methyltransferase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Mahmoudi et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Histone H3-K79 methyltransferase | Histone-lysine N-methyltransferase DOT1 domain | S-adenosyl-L-methionine-dependent methyltransferase superfamily |
|---|---|---|---|---|
|
UniProtKB:A0A8M3AUT9
|
1372 | |||
|
UniProtKB:A0A8M2BHW6
|
1523 | |||
|
UniProtKB:A0A8M3AXT4
|
1522 |
Interactions and Pathways
No data available
Plasmids
No data available