Gene
lhx2b
- ID
- ZDB-GENE-051220-1
- Name
- LIM homeobox 2b
- Symbol
- lhx2b Nomenclature History
- Previous Names
-
- lhx2
- bel
- belladonna
- zgc:152707
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in several processes, including camera-type eye development; nervous system development; and optomotor response. Predicted to localize to nucleus. Used to study congenital nystagmus and pathologic nystagmus. Is expressed in several structures, including brain; forebrain neural keel; forebrain neural rod; optic vesicle; and retina. Orthologous to human LHX2 (LIM homeobox 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 15 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| congenital nystagmus | lhx2btv42z/tv42z | standard conditions | Huang et al., 2006 |
| congenital nystagmus | lhx2btv42z/tv42z | standard conditions | (3) |
| pathologic nystagmus | lhx2btv42z/tv42z | control | Bögli et al., 2017 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Homeobox, conserved site | Homeobox domain | Homeobox-like domain superfamily | Zinc finger, LIM-type |
|---|---|---|---|---|---|
|
UniProtKB:B0R107
|
427 | ||||
|
UniProtKB:A0A8M2BEV2
|
355 | ||||
|
UniProtKB:A0A8M2BFE8
|
426 |
Interactions and Pathways
No data available
Plasmids
No data available