Gene
gli2b
- ID
- ZDB-GENE-050523-1
- Name
- GLI family zinc finger 2b
- Symbol
- gli2b Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription factor activity and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in central nervous system development and dorsal/ventral pattern formation. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Culler-Jones syndrome; holoprosencephaly 9; and spina bifida. Is expressed in adenohypophyseal placode; central nervous system; neural keel; and neural tube. Orthologous to human GLI2 (GLI family zinc finger 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Culler-Jones syndrome | Alliance | Culler-Jones syndrome | 615849 |
| holoprosencephaly 9 | Alliance | Holoprosencephaly 9 | 610829 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | C2H2-type zinc-finger protein GLI-like | Zinc finger C2H2 superfamily | Zinc finger C2H2-type |
|---|---|---|---|---|
|
UniProtKB:Q5BN24
|
1363 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available