Gene

letm1

ID
ZDB-GENE-050522-154
Name
leucine zipper-EF-hand containing transmembrane protein 1
Symbol
letm1 Nomenclature History
Previous Names
  • fc31h08
  • fc58h01
  • wu:fc31h08 (1)
  • wu:fc58h01 (1)
  • zgc:109969 (1)
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to have calcium:proton antiporter activity. Predicted to be involved in cellular calcium ion homeostasis and protein complex oligomerization. Predicted to localize to mitochondrial inner membrane. Orthologous to human LETM1 (leucine zipper and EF-hand containing transmembrane protein 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With letm1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Neurodegeneration, childhood-onset, with multisystem involvement due to mitochondrial dysfunction 620089
Associated With letm1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR018247 EF-Hand 1, calcium-binding site
Domain IPR002048 EF-hand domain
Domain IPR033122 LETM1-like, ribosome-binding domain
Family IPR044202 LETM1/MDM38-like
Homologous_superfamily IPR011992 EF-hand domain pair
Domain Details Per Protein
Protein Length EF-Hand 1, calcium-binding site EF-hand domain EF-hand domain pair LETM1-like, ribosome-binding domain LETM1/MDM38-like
UniProtKB:A0A8M2B3G3 774
UniProtKB:A0A8M3BEI6 779
UniProtKB:A0A8M3AYY0 785
UniProtKB:A0A8M3AYW7 768
UniProtKB:Q1LY46 757
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations