Gene
tap1
- ID
- ZDB-GENE-050517-43
- Name
- transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
- Symbol
- tap1 Nomenclature History
- Previous Names
-
- abcb2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to have ATPase-coupled peptide antigen transmembrane transporter activity; MHC class I protein binding activity; and TAP2 binding activity. Predicted to be involved in peptide transport and transmembrane transport. Predicted to localize to MHC class I peptide loading complex. Human ortholog(s) of this gene implicated in several diseases, including MHC class I deficiency; bone inflammation disease (multiple); bronchial disease (multiple); diffuse scleroderma; and lung disease (multiple). Orthologous to human TAP1 (transporter 1, ATP binding cassette subfamily B member).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Xu et al., 2017
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| MHC class I deficiency | Alliance | Bare lymphocyte syndrome, type I | 604571 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017871 | ABC transporter-like, conserved site |
| Domain | IPR003439 | ABC transporter-like, ATP-binding domain |
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR011527 | ABC transporter type 1, transmembrane domain |
| Family | IPR039421 | Type 1 protein exporter |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036640 | ABC transporter type 1, transmembrane domain superfamily |
Domain Details Per Protein
| Protein | Length | AAA+ ATPase domain | ABC transporter-like, ATP-binding domain | ABC transporter-like, conserved site | ABC transporter type 1, transmembrane domain | ABC transporter type 1, transmembrane domain superfamily | P-loop containing nucleoside triphosphate hydrolase | Type 1 protein exporter |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:E7F8A9
|
731 |
Interactions and Pathways
No data available
Plasmids
No data available