Gene

abca3b

ID

ZDB-GENE-050517-2

Name

ATP-binding cassette, sub-family A (ABC1), member 3b

Symbol

abca3b Nomenclature History

Previous Names

abca3
si:ch211-155i15.6

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to have ATPase-coupled transmembrane transporter activity and lipid transporter activity. Predicted to be involved in lipid transport. Predicted to localize to intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in pulmonary alveolar proteinosis. Is expressed in swim bladder. Orthologous to human ABCA3 (ATP binding cassette subfamily A member 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Chen et al., 2018

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With abca3b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
pulmonary alveolar proteinosis	Alliance	Surfactant metabolism dysfunction, pulmonary, 3	610921

Associated With abca3b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017871	ABC transporter-like, conserved site
Domain	IPR003439	ABC transporter-like, ATP-binding domain
Domain	IPR003593	AAA+ ATPase domain
Domain	IPR013525	ABC-2 type transporter, transmembrane domain
Family	IPR026082	ABC transporter A
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase

Domain Details Per Protein

Protein	Length	AAA+ ATPase domain	ABC-2 type transporter, transmembrane domain	ABC transporter A	ABC transporter-like, ATP-binding domain	ABC transporter-like, conserved site	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A0A8M9Q293 InterPro	1703

Transcripts

Genome Browsers

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	abca3b-202 (1) Ensembl	Havana	4994 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations