Gene

il4r.1

ID

ZDB-GENE-050227-5

Name

interleukin 4 receptor, tandem duplicate 1

Symbol

il4r.1 Nomenclature History

Previous Names

il4r
DrIL-4Ralpha (1)
il-4alpha (1)
zgc:113063

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Exhibits interleukin-4 binding activity. Involved in neurogenesis and regeneration. Localizes to plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including acne; allergic conjunctivitis; human immunodeficiency virus infectious disease; multiple sclerosis (multiple); and renal tuberculosis. Is expressed in several structures, including digestive system; gill; immune system; integument; and ovary. Orthologous to human IL4R (interleukin 4 receptor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 7 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:113063 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With il4r.1 Human Ortholog

No data available

Associated With il4r.1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR015319	Interleukin-4 receptor alpha, N-terminal
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036116	Fibronectin type III superfamily

Domain Details Per Protein

Protein	Length	Fibronectin type III superfamily	Immunoglobulin-like fold	Interleukin-4 receptor alpha, N-terminal
UniProtKB:B2BJ88 InterPro	368
UniProtKB:F1QH70 InterPro	624
UniProtKB:A8WHA2 InterPro	421
UniProtKB:B2BJ89 InterPro	220
UniProtKB:A0A8M2BBP4 InterPro	623
UniProtKB:Q5EAS6 InterPro	220