Gene
bace2
- ID
- ZDB-GENE-041010-68
- Name
- beta-secretase 2
- Symbol
- bace2 Nomenclature History
- Previous Names
-
- bace2l
- zbace (1)
- fi26d02
- wu:fi26d02
- zgc:103530
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to have aspartic-type endopeptidase activity. Involved in melanocyte migration. Predicted to localize to endosome; membrane; and trans-Golgi network. Human ortholog(s) of this gene implicated in Alzheimer's disease. Is expressed in neural crest; optic vesicle; pigment cell; polster; and retina. Orthologous to human BACE2 (beta-secretase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7142521 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR001969 | Aspartic peptidase, active site |
| Domain | IPR033121 | Peptidase family A1 domain |
| Domain | IPR033874 | Memapsin-like |
| Family | IPR001461 | Aspartic peptidase A1 family |
| Family | IPR009119 | Beta-secretase BACE |
| Family | IPR009120 | Beta-secretase BACE1 |
| Homologous_superfamily | IPR021109 | Aspartic peptidase domain superfamily |
Domain Details Per Protein
| Protein | Length | Aspartic peptidase A1 family | Aspartic peptidase, active site | Aspartic peptidase domain superfamily | Beta-secretase BACE | Beta-secretase BACE1 | Memapsin-like | Peptidase family A1 domain |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q5XJ89
|
372 | |||||||
|
UniProtKB:A0A8M3AH32
|
503 |
Interactions and Pathways
No data available
Plasmids
No data available