Gene

eef1a2

ID

ZDB-GENE-040718-64

Name

eukaryotic translation elongation factor 1 alpha 2

Symbol

eef1a2 Nomenclature History

Previous Names

zgc:92085

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to have GTPase activity and translation elongation factor activity. Predicted to be involved in translational elongation. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 38; early infantile epileptic encephalopathy 33; and ovarian cancer. Orthologous to human EEF1A2 (eukaryotic translation elongation factor 1 alpha 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With eef1a2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant intellectual developmental disorder 38	Alliance	Intellectual developmental disorder, autosomal dominant 38	616393
developmental and epileptic encephalopathy 33	Alliance	Developmental and epileptic encephalopathy 33	616409

Associated With eef1a2 Via Experimental Models

Human Disease	Fish	Conditions	Citations
epilepsy	eef1a2^s3012/s3012	standard conditions	Griffin et al., 2021

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR031157	Tr-type G domain, conserved site
Domain	IPR000795	Translational (tr)-type GTP-binding domain
Domain	IPR004160	Translation elongation factor EFTu/EF1A, C-terminal
Domain	IPR004161	Translation elongation factor EFTu-like, domain 2
Family	IPR004539	Translation elongation factor EF1A, eukaryotic/archaeal
Homologous_superfamily	IPR009000	Translation protein, beta-barrel domain superfamily
Homologous_superfamily	IPR009001	Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase