Gene
dguok
- ID
- ZDB-GENE-040625-14
- Name
- deoxyguanosine kinase
- Symbol
- dguok Nomenclature History
- Previous Names
-
- zgc:86625
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have deoxyguanosine kinase activity. Predicted to be involved in nucleobase-containing compound metabolic process. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 4; mitochondrial DNA depletion syndrome 3; and mitochondrial metabolism disease. Orthologous to human DGUOK (deoxyguanosine kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6892866 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 4 | Alliance | Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 4 | 617070 |
| mitochondrial DNA depletion syndrome 3 | Alliance | Mitochondrial DNA depletion syndrome 3 (hepatocerebral type) | 251880 |
| Portal hypertension, noncirrhotic, 1 | 617068 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Deoxynucleoside kinase | Deoxynucleoside kinase domain | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|
|
UniProtKB:A0A8M9Q805
|
181 | |||
|
UniProtKB:A5WUY2
|
269 |
Interactions and Pathways
No data available
Plasmids
No data available