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General Information
ZIRC
ZFIN ID: ZDB-GENE-040428-1
Gene Name: retinoblastoma 1
Gene Symbol: rb1
GO Details
Ontology Qualifier Term Evidence Inferred From Annotation Extension Reference(s)
Molecular Function RNA polymerase II activating transcription factor binding IBA PANTHER:PTN000348425, MGI:MGI:97874 Gaudet et al., 2010
RNA polymerase II regulatory region DNA binding IBA PANTHER:PTN000348425, FB:FBgn0015799 Gaudet et al., 2010
transcription factor binding IEA InterPro:IPR033057 ZFIN Electronic Annotation
Cellular Component chromatin IBA RGD:3541, PANTHER:PTN000348425, FB:FBgn0015799 Gaudet et al., 2010
nucleus IEA InterPro:IPR002719 ZFIN Electronic Annotation
nucleus IEA InterPro:IPR002720 ZFIN Electronic Annotation
COLOCALIZES WITH nucleus IBA WB:WBGene00003020, UniProtKB:Q9LKZ3, RGD:3540, MGI:MGI:103300, UniProtKB:Q08999, UniProtKB:P06400, PANTHER:PTN000348425, MGI:MGI:105085, MGI:MGI:97874, FB:FBgn0015799 Gaudet et al., 2010
Rb-E2F complex IBA PANTHER:PTN000348429, UniProtKB:P06400, MGI:MGI:97874 Gaudet et al., 2010
Rb-E2F complex IEA InterPro:IPR033057 ZFIN Electronic Annotation
transcription factor complex IBA MGI:MGI:103300, PANTHER:PTN000348425, MGI:MGI:105085, MGI:MGI:97874 Gaudet et al., 2010
Biological Process activation of cysteine-type endopeptidase activity involved in apoptotic process IGI e2f1 Zhang et al., 2017
activation of cysteine-type endopeptidase activity involved in apoptotic process IMP rb1sm11/sm11 Zhang et al., 2017
anatomical structure maturation IGI rb1 results_in_maturation_of(anatomical structure) Zhang et al., 2017
anatomical structure maturation IGI e2f1 results_in_maturation_of(anatomical structure) Zhang et al., 2017
anatomical structure maturation IMP MO1-e2f1 results_in_maturation_of(anatomical structure) Zhang et al., 2017
anatomical structure maturation IMP rb1sm11/sm11 results_in_maturation_of(anatomical structure) Zhang et al., 2017
apoptotic process IEA InterPro:IPR033057 ZFIN Electronic Annotation
cell differentiation IBA UniProtKB:Q9LKZ3, PANTHER:PTN000348425 Gaudet et al., 2010
cell maturation IGI rb1 results_in_maturation_of(anatomical structure) Zhang et al., 2017
cell maturation IGI e2f1 results_in_maturation_of(anatomical structure) Zhang et al., 2017
cell maturation IMP MO1-e2f1 results_in_maturation_of(anatomical structure) Zhang et al., 2017
cell maturation IMP rb1sm11/sm11 results_in_maturation_of(anatomical structure) Zhang et al., 2017
cell morphogenesis involved in neuron differentiation IBA PANTHER:PTN000348429, MGI:MGI:97874 Gaudet et al., 2010
negative regulation of cell population proliferation IEA InterPro:IPR033057 ZFIN Electronic Annotation
negative regulation of G1/S transition of mitotic cell cycle IBA PANTHER:PTN000348425, FB:FBgn0038390, MGI:MGI:97874, FB:FBgn0015799 Gaudet et al., 2010
negative regulation of G1/S transition of mitotic cell cycle IEA InterPro:IPR033057 ZFIN Electronic Annotation
negative regulation of transcription, DNA-templated IEA InterPro:IPR033057 ZFIN Electronic Annotation
neuron differentiation IBA PANTHER:PTN000348429, MGI:MGI:97874 Gaudet et al., 2010
neuron projection development IBA PANTHER:PTN000348429, MGI:MGI:97874 Gaudet et al., 2010
optic nerve development IMP rb1te226a/te226a Gyda et al., 2012
regulation of cell cycle IEA InterPro:IPR002719 ZFIN Electronic Annotation
regulation of cell cycle IEA InterPro:IPR002720 ZFIN Electronic Annotation
regulation of cell cycle IEA InterPro:IPR028309 ZFIN Electronic Annotation
regulation of mitotic cell cycle IBA UniProtKB:P06400, PANTHER:PTN000348425 Gaudet et al., 2010
regulation of transcription by RNA polymerase II IEA InterPro:IPR028309 ZFIN Electronic Annotation
retinal ganglion cell axon guidance IMP rb1te226a/te226a Gyda et al., 2012
visual perception IMP rb1te226a/te226a Gyda et al., 2012