Gene

sqstm1

ID

ZDB-GENE-040426-2204

Name

sequestosome 1

Symbol

sqstm1 Nomenclature History

Previous Names

p62 (1)
sb:cb621
zgc:85784 (1)

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to have K63-linked polyubiquitin modification-dependent protein binding activity and protein kinase C binding activity. Involved in axonogenesis; locomotory behavior; and regulation of autophagy. Predicted to localize to aggresome and amphisome. Human ortholog(s) of this gene implicated in FTDALS3 and Paget's disease of bone. Is expressed in several structures, including digestive system; epidermis; mesoderm; nervous system; and tail bud. Orthologous to human SQSTM1 (sequestosome 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

29 figures from 22 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

cb621 (12 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sqstm1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
distal myopathy with rimmed vacuoles	Alliance	Myopathy, distal, with rimmed vacuoles	617158
frontotemporal dementia and/or amyotrophic lateral sclerosis 3	Alliance	Frontotemporal dementia and/or amyotrophic lateral sclerosis 3	616437
neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset	Alliance	Neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset	617145
Paget's disease of bone 3	Alliance	Paget disease of bone 3	167250

Associated With sqstm1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000270	PB1 domain
Domain	IPR000433	Zinc finger, ZZ-type
Domain	IPR015940	Ubiquitin-associated domain
Domain	IPR033741	Sequestosome-1, UBA domain
Domain	IPR034866	Sequestosome-1, PB1 domain
Homologous_superfamily	IPR009060	UBA-like superfamily
Homologous_superfamily	IPR043145	Zinc finger, ZZ-type superfamily

Domain Details Per Protein

Protein	Length	PB1 domain	Sequestosome-1, PB1 domain	Sequestosome-1, UBA domain	UBA-like superfamily	Ubiquitin-associated domain	Zinc finger, ZZ-type	Zinc finger, ZZ-type superfamily
UniProtKB:F1Q5Z8 InterPro	452

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	sqstm1-202 (1) Ensembl	Havana	1939 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	sqstm1-003 (1) Ensembl	Havana	531 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	sqstm1-004 (1) Ensembl	Havana	1010 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab4-sqstm1	polyclonal	sqstm1		Rabbit	IHC WB	MBL International	20
Ab10-sqstm1	polyclonal	sqstm1		Rabbit	IHC	Enzo Life Sciences International, Inc.	1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations