Gene
eif2b3
- ID
- ZDB-GENE-040426-1039
- Name
- eukaryotic translation initiation factor 2B, subunit 3 gamma
- Symbol
- eif2b3 Nomenclature History
- Previous Names
-
- zgc:56473 (1)
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have guanyl-nucleotide exchange factor activity and translation initiation factor activity. Predicted to be involved in cytoplasmic translational initiation. Predicted to localize to eukaryotic translation initiation factor 2B complex and guanyl-nucleotide exchange factor complex. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter. Is expressed in eye and gut. Orthologous to human EIF2B3 (eukaryotic translation initiation factor 2B subunit gamma).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6909645 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 12 figures from 2 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| leukoencephalopathy with vanishing white matter 3 | Alliance | Leukoencephalopathy with vanishing white matter 3, with or without ovarian failure | 620313 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| leukoencephalopathy with vanishing white matter | eif2b3ck156a/ck156a | standard conditions | (2) |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Nucleotide-diphospho-sugar transferases | Nucleotidyl transferase domain |
|---|---|---|---|
|
UniProtKB:Q7ZTY5
|
453 |
| Type | Name | Annotation Method | Length (nt) | Analysis |
|---|---|---|---|---|
| mRNA |
eif2b3-201
(1)
|
Havana | 1737 nt | |
| mRNA |
eif2b3-202
(1)
|
Havana | 698 nt |
Interactions and Pathways
No data available
Plasmids
No data available