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General Information
ZIRC
ZFIN ID: ZDB-GENE-040219-3
Gene Name: MYD88 innate immune signal transduction adaptor
Gene Symbol: myd88
GO Details
Ontology Qualifier Term Evidence Inferred From Annotation Extension Reference(s)
Molecular Function protein binding IPI irf1b Feng et al., 2016
protein binding IPI sigirr Feng et al., 2016
TIR domain binding IEA InterPro:IPR017281 ZFIN Electronic Annotation
Toll-like receptor binding IBA MGI:MGI:108005, PANTHER:PTN000386853 Gaudet et al., 2010
Cellular Component cytoplasm IEA UniProtKB-KW:KW-0963 ZFIN Electronic Annotation
cytoplasm IEA UniProtKB-SubCell:SL-0086 UniProt-GOA
plasma membrane IBA MGI:MGI:108005, PANTHER:PTN000386853 Gaudet et al., 2010
Biological Process activation of innate immune response IMP myd88hu3568/hu3568 (AB) van der Vaart et al., 2013
defense response to bacterium IMP MO2-myd88 Fehr et al., 2016
defense response to Gram-positive bacterium IBA MGI:MGI:108005, PANTHER:PTN000386853, FB:FBgn0033402 Gaudet et al., 2010
immune system process IEA UniProtKB-KW:KW-0391 ZFIN Electronic Annotation
inflammatory response IEA UniProtKB-KW:KW-0395 ZFIN Electronic Annotation
innate immune response IBA MGI:MGI:108005, UniProtKB:Q99836, PANTHER:PTN000386853 Gaudet et al., 2010
innate immune response IEA UniProtKB-KW:KW-0399 ZFIN Electronic Annotation
innate immune response IMP MO1-myd88 van der Sar et al., 2006
monocyte activation IMP MO2-myd88 Cambier et al., 2017
MyD88-dependent toll-like receptor signaling pathway IEA InterPro:IPR017281 ZFIN Electronic Annotation
neutrophil activation involved in immune response IMP MO2-myd88 Cambier et al., 2017
neutrophil chemotaxis IGI il1b Yan et al., 2014
neutrophil chemotaxis IMP MO2-myd88, MO4-myd88 Yan et al., 2014
positive regulation of hematopoietic progenitor cell differentiation IMP MO1-myd88 He et al., 2015
positive regulation of hematopoietic progenitor cell differentiation IMP myd88hu3568/hu3568 He et al., 2015
positive regulation of I-kappaB kinase/NF-kappaB signaling IEA InterPro:IPR017281 ZFIN Electronic Annotation
regulation of hematopoietic progenitor cell differentiation IGI nfkbiaa He et al., 2015
response to molecule of bacterial origin IMP MO1-myd88 Alcaraz-Perez et al., 2008
signal transduction IEA InterPro:IPR000157 ZFIN Electronic Annotation
signal transduction IEA InterPro:IPR000488 ZFIN Electronic Annotation
signal transduction IEA InterPro:IPR034249 ZFIN Electronic Annotation
Toll signaling pathway IBA PANTHER:PTN000386853, RGD:735043, FB:FBgn0033402 Gaudet et al., 2010