Gene
ahcy
- ID
- ZDB-GENE-031219-6
- Name
- adenosylhomocysteinase
- Symbol
- ahcy Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to have adenosylhomocysteinase activity. Involved in S-adenosylmethionine cycle. Predicted to localize to cytosol. Used to study fatty liver disease and non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase. Is expressed in several structures, including brain; digestive system; immature eye; musculature system; and neural tube. Orthologous to human AHCY (adenosylhomocysteinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb1079 (6 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase | Alliance | Hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase | 613752 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| steatotic liver disease | ahcyp14nb/p14nb | standard conditions | (2) |
| metabolic dysfunction-associated steatotic liver disease | ahcyp14nb/+ | control | Sapp et al., 2014 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020082 | S-adenosyl-L-homocysteine hydrolase, conserved site |
| Domain | IPR015878 | S-adenosyl-L-homocysteine hydrolase, NAD binding domain |
| Family | IPR000043 | Adenosylhomocysteinase-like |
| Homologous_superfamily | IPR036291 | NAD(P)-binding domain superfamily |
| Homologous_superfamily | IPR042172 | Adenosylhomocysteinase-like superfamily |
Domain Details Per Protein
| Protein | Length | Adenosylhomocysteinase-like | Adenosylhomocysteinase-like superfamily | NAD(P)-binding domain superfamily | S-adenosyl-L-homocysteine hydrolase, conserved site | S-adenosyl-L-homocysteine hydrolase, NAD binding domain |
|---|---|---|---|---|---|---|
|
UniProtKB:Q803T5
|
433 |
Interactions and Pathways
No data available
Plasmids
No data available