Gene

smad9

ID

ZDB-GENE-031014-1

Name

SMAD family member 9

Symbol

smad9 Nomenclature History

Previous Names

madh9
smad8
zgc:103407 (1)

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to have DNA binding activity and DNA-binding transcription factor activity. Involved in dorsal/ventral pattern formation; myeloid cell development; and negative regulation of transcription, DNA-templated. Predicted to localize to several cellular components, including integral component of membrane; nucleus; and transcription factor complex. Used to study arteriovenous malformations of the brain. Human ortholog(s) of this gene implicated in primary pulmonary hypertension. Is expressed in several structures, including cardiovascular system; gut; nervous system; optic vesicle; and periderm. Orthologous to human SMAD9 (SMAD family member 9).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

13 figures from 6 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:103407 (19 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With smad9 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
primary pulmonary hypertension	Alliance	Pulmonary hypertension, primary, 2	615342

Associated With smad9 Via Experimental Models

Human Disease	Fish	Conditions	Citations
arteriovenous malformations of the brain	zf531Tg + MO1-smad9	standard conditions	Walcott et al., 2018

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001132	SMAD domain, Dwarfin-type
Domain	IPR003619	MAD homology 1, Dwarfin-type
Domain	IPR013019	MAD homology, MH1
Family	IPR013790	Dwarfin
Homologous_superfamily	IPR008984	SMAD/FHA domain superfamily
Homologous_superfamily	IPR017855	SMAD-like domain superfamily
Homologous_superfamily	IPR036578	SMAD MH1 domain superfamily

Domain Details Per Protein

Protein	Length	Dwarfin	MAD homology 1, Dwarfin-type	MAD homology, MH1	SMAD domain, Dwarfin-type	SMAD/FHA domain superfamily	SMAD-like domain superfamily	SMAD MH1 domain superfamily
UniProtKB:F1QXZ9 InterPro	466

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	smad9-001 (1) Ensembl	Havana	2359 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	smad9-002 (1) Ensembl	Havana	917 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	smad9-003 (1) Ensembl	Havana	526 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-smad	polyclonal	smad1 smad5 smad9	IgG	Rabbit	IHC WB	Cell Signaling Technology, Inc.	77

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations