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General Information
ZIRC
ZFIN ID: ZDB-GENE-030909-1
Gene Name: SRY-box transcription factor 2
Gene Symbol: sox2
GO Details
Ontology Qualifier Term Evidence Inferred From Annotation Extension Reference(s)
Molecular Function chromatin binding IDA Kotkamp et al., 2014
DNA binding IEA InterPro:IPR032643 ZFIN Electronic Annotation
DNA binding IEA UniProtKB-KW:KW-0238 ZFIN Electronic Annotation
CONTRIBUTES TO DNA-binding transcription factor activity IDA Okuda et al., 2006
DNA-binding transcription factor activity, RNA polymerase II-specific IBA MGI:MGI:107543, UniProtKB:Q05066, UniProtKB:P35713, UniProtKB:Q06945, MGI:MGI:98359, MGI:MGI:98357, FB:FBgn0000411, MGI:MGI:98369, MGI:MGI:98366, MGI:MGI:98364, RGD:69351, MGI:MGI:103559, MGI:MGI:98362, MGI:MGI:98363, MGI:MGI:98660, MGI:MGI:98360, FB:FBgn0029123, PANTHER:PTN000030384, PomBase:SPBC23G7.09, MGI:MGI:2654070 Gaudet et al., 2010
sequence-specific DNA binding IDA Leichsenring et al., 2013
sequence-specific DNA binding IPI sox19b Leichsenring et al., 2013
sequence-specific DNA binding IPI bambia Leichsenring et al., 2013
sequence-specific DNA binding IPI nanog Leichsenring et al., 2013
sequence-specific DNA binding IPI sox2 Leichsenring et al., 2013
sequence-specific DNA binding IPI sox19a Leichsenring et al., 2013
sequence-specific DNA binding IPI sox3 Leichsenring et al., 2013
sequence-specific DNA binding IPI pou5f3 Leichsenring et al., 2013
sequence-specific DNA binding IPI foxd5 Leichsenring et al., 2013
Cellular Component cytoplasm IEA UniProtKB-KW:KW-0963 ZFIN Electronic Annotation
cytoplasm IEA UniProtKB-SubCell:SL-0086 UniProt-GOA
nuclear transcription factor complex IBA MGI:MGI:98366, MGI:MGI:98364, MGI:MGI:107543, MGI:MGI:98362, MGI:MGI:103559, MGI:MGI:98363, MGI:MGI:98660, PANTHER:PTN000030384, PomBase:SPBC23G7.09 Gaudet et al., 2010
nucleus IBA MGI:MGI:107543, UniProtKB:Q05066, FB:FBgn0005613, FB:FBgn0005612, RGD:1565646, MGI:MGI:98369, FB:FBgn0029123, PANTHER:PTN000030384, UniProtKB:P48431, UniProtKB:P48430, WB:WBGene00004771, UniProtKB:Q9H6I2, UniProtKB:P35713, UniProtKB:Q06945, MGI:MGI:98359, UniProtKB:P35716, MGI:MGI:98357, FB:FBgn0000411, MGI:MGI:98366, MGI:MGI:98364, RGD:69351, MGI:MGI:103559, UniProtKB:Q9BT81, MGI:MGI:98362, MGI:MGI:98363, MGI:MGI:98660, FB:FBgn0036411 Gaudet et al., 2010
nucleus IEA InterPro:IPR032643 ZFIN Electronic Annotation
nucleus IEA UniProtKB-KW:KW-0539 ZFIN Electronic Annotation
transcription factor complex IC DNA-binding transcription factor activity Okuda et al., 2006
Biological Process anatomical structure morphogenesis IBA MGI:MGI:98366, MGI:MGI:98364, MGI:MGI:107543, MGI:MGI:98365, MGI:MGI:103559, UniProtKB:P35713, PANTHER:PTN000030384, MGI:MGI:98359, MGI:MGI:98357, FB:FBgn0000411 Gaudet et al., 2010
cell differentiation IBA UniProtKB:P48431, MGI:MGI:98364, MGI:MGI:107543, MGI:MGI:98365, MGI:MGI:103559, MGI:MGI:98363, UniProtKB:Q9Y651, PANTHER:PTN000030384, MGI:MGI:98359, UniProtKB:P35716, UniProtKB:O15370 Gaudet et al., 2010
cell population proliferation IMP MO3-sox2 Ogai et al., 2014
cell population proliferation IMP MO3-sox2 occurs_in(ependymal cell) Ogai et al., 2014
cell population proliferation IMP MO7-sox2 Ogai et al., 2014
cell population proliferation IMP MO7-sox2 occurs_in(ependymal cell) Ogai et al., 2014
epithalamus development IMP MO6-sox2 Pavlou et al., 2014
eye morphogenesis IMP MO1-sox2 Pujic et al., 2006
eye morphogenesis IMP MO2-sox2 Pujic et al., 2006
fin regeneration IMP MO1-sox2 Christen et al., 2010
inner ear development IBA PANTHER:PTN001616016 Gaudet et al., 2010
inner ear receptor cell development IGI s356tTg; x20Tg; x21Tg Millimaki et al., 2010
inner ear receptor cell development IGI s356tTg; x20Tg , MO2-sox2 Millimaki et al., 2010
inner ear receptor cell development IMP MO2-sox2 Millimaki et al., 2010
multicellular organism development IEA UniProtKB-KW:KW-0217 ZFIN Electronic Annotation
otic placode development IMP sox2x50/x50 (AB) Gou et al., 2018
otic vesicle development IMP sox2x50/x50 (AB) Gou et al., 2018
pineal gland development IMP MO6-sox2 Pavlou et al., 2014
positive regulation of DNA-binding transcription factor activity IDA Okuda et al., 2006
regeneration IMP MO2-sox2 Millimaki et al., 2010
regulation of transcription, DNA-templated IBA UniProtKB:P48431, UniProtKB:Q9W7R5, MGI:MGI:107543, UniProtKB:Q05066, UniProtKB:P48430, UniProtKB:Q06945, UniProtKB:Q9W7R6, MGI:MGI:98359, FB:FBgn0005613, FB:FBgn0005612, MGI:MGI:98369, FB:FBgn0000411, MGI:MGI:98366, RGD:69351, MGI:MGI:98364, MGI:MGI:103559, UniProtKB:Q9BT81, PANTHER:PTN000030384, MGI:MGI:2654070 Gaudet et al., 2010
regulation of transcription, DNA-templated IEA InterPro:IPR022097 ZFIN Electronic Annotation
regulation of transcription, DNA-templated IEA InterPro:IPR032643 ZFIN Electronic Annotation