Gene
ada2a
- ID
- ZDB-GENE-030902-4
- Name
- adenosine deaminase 2a
- Symbol
- ada2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to have several functions, including adenosine deaminase activity; proteoglycan binding activity; and zinc ion binding activity. Predicted to be involved in adenosine catabolic process and inosine biosynthetic process. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in Sneddon syndrome. Is expressed in several structures, including cardiovascular system; gill; kidney; liver; and notochord. Orthologous to human ADA2 (adenosine deaminase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55247 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Sneddon syndrome | Alliance | Sneddon syndrome | 182410 |
| Vasculitis, autoinflammation, immunodeficiency, and hematologic defects syndrome | 615688 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Adenosine/adenine deaminase | Adenosine/AMP deaminase N-terminal | Adenosine deaminase domain | Adenosine deaminase-related growth factor | Metal-dependent hydrolase |
|---|---|---|---|---|---|---|
|
UniProtKB:P58781
|
503 |
Interactions and Pathways
No data available
Plasmids
No data available