Gene

pak1

ID

ZDB-GENE-030826-29

Name

p21 protein (Cdc42/Rac)-activated kinase 1

Symbol

pak1 Nomenclature History

Previous Names

cb761 (1)
wu:fj97h10

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Exhibits identical protein binding activity and protein kinase activity. Involved in several processes, including animal organ development; convergent extension; and dorsal/ventral axis specification. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in breast cancer; renal cell carcinoma; and schizophrenia. Is expressed in several structures, including axial mesoderm; cardiovascular system; nervous system; neural tube; and pectoral fin. Orthologous to human PAK1 (p21 (RAC1) activated kinase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

18 figures from 8 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:55281 (12 images)
cb761 (16 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 8 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pak1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Intellectual developmental disorder with macrocephaly, seizures, and speech delay	618158

Associated With pak1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000095	CRIB domain
Domain	IPR000719	Protein kinase domain
Domain	IPR033923	p21 activated kinase binding domain
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR036936	CRIB domain superfamily

Domain Details Per Protein

Protein	Length	CRIB domain	CRIB domain superfamily	p21 activated kinase binding domain	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine-protein kinase, active site
UniProtKB:A0A8M9P9X9 InterPro	587
UniProtKB:Q803Z0 InterPro	577
UniProtKB:A0A8M9PFA6 InterPro	579

Transcripts

Genome Browsers

NCBI

No data available

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-pak		pak1 pak2a pak2b		Rabbit	IHC		2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations