ZFIN ID: ZDB-GENE-030131-9498
Gene Name: methyltransferase like 3
Gene Symbol: mettl3
GO Details
Ontology Qualifier Term Evidence Inferred From Annotation Extension Reference(s)
Molecular Function methyltransferase activity IEA UniProtKB-KW:KW-0489 ZFIN Electronic Annotation
mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity IBA PANTHER:PTN000302828 Gaudet et al., 2010
mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity IEA InterPro:IPR025848 ZFIN Electronic Annotation
mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity IMP mettl3ihb306/ihb306 (AB) Xia et al., 2017
mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity IMP mettl3ihb307/ihb307 (AB) Xia et al., 2017
mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity ISS UniProtKB:Q86U44 GOA et al., 2007
mRNA (N6-adenosine)-methyltransferase activity IMP MO1-mettl3 Zhang et al., 2017
mRNA (N6-adenosine)-methyltransferase activity ISS UniProtKB:Q86U44 GOA et al., 2007
mRNA (N6-adenosine)-methyltransferase activity ISS UniProtKB:Q8C3P7 GOA et al., 2007
mRNA binding ISS UniProtKB:Q86U44 GOA et al., 2007
protein heterodimerization activity ISS UniProtKB:Q86U44 GOA et al., 2007
RNA binding IEA UniProtKB-KW:KW-0694 ZFIN Electronic Annotation
S-adenosyl-L-methionine binding ISS UniProtKB:Q86U44 GOA et al., 2007
transferase activity IEA UniProtKB-KW:KW-0808 ZFIN Electronic Annotation
Cellular Component cytoplasm IEA UniProtKB-KW:KW-0963 ZFIN Electronic Annotation
cytoplasm IEA UniProtKB-SubCell:SL-0086 UniProt-GOA
nuclear speck IBA PANTHER:PTN000302828 Gaudet et al., 2010
nuclear speck ISS UniProtKB:Q86U44 GOA et al., 2007
nucleus IEA InterPro:IPR025848 ZFIN Electronic Annotation
nucleus IEA UniProtKB-KW:KW-0539 ZFIN Electronic Annotation
nucleus ISS UniProtKB:Q8C3P7 GOA et al., 2007
RNA N6-methyladenosine methyltransferase complex IBA PANTHER:PTN000302828 Gaudet et al., 2010
RNA N6-methyladenosine methyltransferase complex ISS UniProtKB:Q86U44 GOA et al., 2007
Biological Process adenosine to inosine editing ISS UniProtKB:Q8C3P7 GOA et al., 2007
cell differentiation IEA UniProtKB-KW:KW-0221 ZFIN Electronic Annotation
cellular response to DNA damage stimulus IEA UniProtKB-KW:KW-0227 ZFIN Electronic Annotation
cellular response to DNA damage stimulus ISS UniProtKB:Q86U44 GOA et al., 2007
cellular response to UV ISS UniProtKB:Q86U44 GOA et al., 2007
endothelial to hematopoietic transition IMP Zhang et al., 2017
flagellated sperm motility IMP mettl3ihb306/ihb306 (AB) Xia et al., 2017
flagellated sperm motility IMP mettl3ihb307/ihb307 (AB) Xia et al., 2017
forebrain radial glial cell differentiation ISS UniProtKB:Q8C3P7 GOA et al., 2007
hematopoietic stem cell proliferation IMP MO1-mettl3 Zhang et al., 2017
methylation IEA UniProtKB-KW:KW-0489 ZFIN Electronic Annotation
mRNA catabolic process ISS UniProtKB:Q8C3P7 GOA et al., 2007
mRNA destabilization ISS UniProtKB:Q8C3P7 GOA et al., 2007
mRNA methylation IMP Zhang et al., 2017
mRNA methylation IMP MO1-mettl3 Zhang et al., 2017
mRNA splicing, via spliceosome IBA PANTHER:PTN000981980 Gaudet et al., 2010
mRNA splicing, via spliceosome ISS UniProtKB:Q8C3P7 GOA et al., 2007
NOT mRNA splicing, via spliceosome ISS UniProtKB:Q8C3P7 GOA et al., 2007
negative regulation of Notch signaling pathway IMP Zhang et al., 2017
negative regulation of Notch signaling pathway IMP MO1-mettl3 Zhang et al., 2017
Notch signaling pathway involved in arterial endothelial cell fate commitment IMP MO1-mettl3 Zhang et al., 2017
oocyte maturation IMP mettl3ihb306/ihb306 (AB) Xia et al., 2017
oocyte maturation IMP mettl3ihb307/ihb307 (AB) Xia et al., 2017
positive regulation of cap-independent translational initiation ISS UniProtKB:Q86U44 GOA et al., 2007
primary miRNA methylation IBA PANTHER:PTN000981980 Gaudet et al., 2010
primary miRNA methylation ISS UniProtKB:Q86U44 GOA et al., 2007
regulation of apoptotic process IGI MO1-mettl3, MO1-wtap Ping et al., 2014
regulation of hematopoietic stem cell differentiation IMP Zhang et al., 2017
regulation of meiotic cell cycle ISS UniProtKB:Q8C3P7 GOA et al., 2007
regulation of mRNA modification IMP MO1-mettl3 Zhang et al., 2017
regulation of T cell differentiation ISS UniProtKB:Q8C3P7 GOA et al., 2007
RNA methylation IEA InterPro:IPR025848 ZFIN Electronic Annotation
sex determination IMP mettl3ihb306/ihb306 (AB) Xia et al., 2017
sex determination IMP mettl3ihb307/ihb307 (AB) Xia et al., 2017
spermatogenesis IEA UniProtKB-KW:KW-0744 ZFIN Electronic Annotation
spermatogenesis ISS UniProtKB:Q8C3P7 GOA et al., 2007
stem cell population maintenance ISS UniProtKB:Q8C3P7 GOA et al., 2007