Gene
hcn2b
- ID
- ZDB-GENE-030131-8228
- Name
- hyperpolarization activated cyclic nucleotide-gated potassium channel 2b
- Symbol
- hcn2b Nomenclature History
- Previous Names
-
- hcn2
- si:dkey-28h18.1
- wu:fj61d07
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to have voltage-gated potassium channel activity. Predicted to be involved in potassium ion transmembrane transport and regulation of ion transmembrane transport. Predicted to localize to integral component of membrane. Orthologous to human HCN2 (hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Trapani et al., 2011
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from RodrÃguez-Ortiz et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial febrile seizures 2 | Alliance | Febrile seizures, familial, 2 | 602477 |
| familial febrile seizures 2 | Alliance | Generalized epilepsy with febrile seizures plus, type 11 | 602477 |
| familial febrile seizures 2 | Alliance | {Epilepsy, idiopathic generalized, susceptibility to, 17} | 602477 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018488 | Cyclic nucleotide-binding, conserved site |
| Domain | IPR000595 | Cyclic nucleotide-binding domain |
| Domain | IPR005821 | Ion transport domain |
| Domain | IPR013621 | Ion transport N-terminal |
| Family | IPR003938 | Potassium channel, voltage-dependent, EAG/ELK/ERG |
| Homologous_superfamily | IPR014710 | RmlC-like jelly roll fold |
| Homologous_superfamily | IPR018490 | Cyclic nucleotide-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Cyclic nucleotide-binding, conserved site | Cyclic nucleotide-binding domain | Cyclic nucleotide-binding domain superfamily | Ion transport domain | Ion transport N-terminal | Potassium channel, voltage-dependent, EAG/ELK/ERG | RmlC-like jelly roll fold |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8N7T6V3
|
979 | |||||||
|
UniProtKB:A0A8M3B5M0
|
538 |
Interactions and Pathways
No data available
Plasmids
No data available