Gene

pcloa

ID

ZDB-GENE-030131-8115

Name

piccolo presynaptic cytomatrix protein a

Symbol

pcloa Nomenclature History

Previous Names

si:dkey-108d22.4
wu:fj53e09

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Predicted to have metal ion binding activity. Predicted to localize to membrane and synapse. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 3. Is expressed in brain; cerebellum; telencephalon; and torus longitudinalis. Orthologous to human PCLO (piccolo presynaptic cytomatrix protein).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Nonet, 2012

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pcloa Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
pontocerebellar hypoplasia type 3	Alliance	?Pontocerebellar hypoplasia, type 3	608027

Associated With pcloa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000008	C2 domain
Domain	IPR001478	PDZ domain
Domain	IPR001565	Synaptotagmin
Domain	IPR008899	Zinc finger, piccolo-type
Homologous_superfamily	IPR011011	Zinc finger, FYVE/PHD-type
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily	IPR035892	C2 domain superfamily
Homologous_superfamily	IPR036034	PDZ superfamily

Domain Details Per Protein

Protein	Length	C2 domain	C2 domain superfamily	PDZ domain	PDZ superfamily	Synaptotagmin	Zinc finger, FYVE/PHD-type	Zinc finger, piccolo-type	Zinc finger, RING/FYVE/PHD-type
UniProtKB:A0A8M9Q6A8 InterPro	4140
UniProtKB:A0A8M9PHT7 InterPro	4281
UniProtKB:A0A8M9PQR0 InterPro	4092
UniProtKB:A0A8M6Z649 InterPro	4290
UniProtKB:A0A8M9PV22 InterPro	4250
UniProtKB:A0A8M3B1P0 InterPro	4313
UniProtKB:A0A8M9PJR5 InterPro	4101
UniProtKB:A0A8M3AYQ2 InterPro	4248
UniProtKB:A0A8M6YZR5 InterPro	4304
UniProtKB:A0A8M9Q1E5 InterPro	4078
UniProtKB:A0A8M9Q115 InterPro	4194
UniProtKB:A0A8M6YX87 InterPro	4259
UniProtKB:A0A8M6Z5J4 InterPro	4196

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	pcloa-202 (1) Ensembl	Havana	13853 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	pcloa-203 (1) Ensembl	Havana	314 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations