Gene

got2b

ID

ZDB-GENE-030131-7917

Name

glutamic-oxaloacetic transaminase 2b, mitochondrial

Symbol

got2b Nomenclature History

Previous Names

fj40h07
wu:fj40h07
zgc:56425

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have L-aspartate:2-oxoglutarate aminotransferase activity. Predicted to be involved in aspartate catabolic process. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy. Is expressed in several structures, including adaxial cell; cardiovascular system; musculature system; nervous system; and pleuroperitoneal region. Orthologous to human GOT2 (glutamic-oxaloacetic transaminase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:56425 (20 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With got2b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
developmental and epileptic encephalopathy 82	Alliance	Developmental and epileptic encephalopathy 82	618721

Associated With got2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR004838	Aminotransferases, class-I, pyridoxal-phosphate-binding site
Domain	IPR004839	Aminotransferase, class I/classII
Family	IPR000796	Aspartate/other aminotransferase
Homologous_superfamily	IPR015421	Pyridoxal phosphate-dependent transferase, major domain
Homologous_superfamily	IPR015422	Pyridoxal phosphate-dependent transferase, small domain
Homologous_superfamily	IPR015424	Pyridoxal phosphate-dependent transferase

Domain Details Per Protein

Protein	Length	Aminotransferase, class I/classII	Aminotransferases, class-I, pyridoxal-phosphate-binding site	Aspartate/other aminotransferase	Pyridoxal phosphate-dependent transferase	Pyridoxal phosphate-dependent transferase, major domain	Pyridoxal phosphate-dependent transferase, small domain
UniProtKB:Q7ZWF5 InterPro	428

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	got2b-201 (1) Ensembl	Havana	1708 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	got2b-002 (1) Ensembl	Havana	800 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations