Gene

cnot3b

ID

ZDB-GENE-030131-5838

Name

CCR4-NOT transcription complex, subunit 3b

Symbol

cnot3b Nomenclature History

Previous Names

cnot3
wu:fi20g07
zgc:55934

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to be involved in negative regulation of translation and nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. Predicted to localize to CCR4-NOT core complex and P-body. Is expressed in several structures, including gut; head; heart; integument; and testis. Orthologous to human CNOT3 (CCR4-NOT transcription complex subunit 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

eu195 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Delacruz et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cnot3b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Intellectual developmental disorder with speech delay, autism, and dysmorphic facies	618672

Associated With cnot3b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR007207	CCR4-Not complex component, Not N-terminal domain
Domain	IPR007282	NOT2/NOT3/NOT5, C-terminal
Family	IPR012270	CCR4-NOT complex, subunit 3/ 5
Family	IPR040168	Not2/Not3/Not5
Homologous_superfamily	IPR038635	CCR4-NOT complex subunit 2/3/5, C-terminal domain superfamily