Gene
clp1
- ID
- ZDB-GENE-030131-5306
- Name
- cleavage factor polyribonucleotide kinase subunit 1
- Symbol
- clp1 Nomenclature History
- Previous Names
-
- fa28a12
- wu:fa28a12 (1)
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Exhibits ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity. Involved in brain development and spinal cord motor neuron differentiation. Predicted to localize to mRNA cleavage factor complex and tRNA-intron endonuclease complex. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 10. Is expressed in brain and motor neurons. Orthologous to human CLP1 (cleavage factor polyribonucleotide kinase subunit 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Schaffer et al., 2014
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Schaffer et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| pontocerebellar hypoplasia type 10 | Alliance | Pontocerebellar hypoplasia, type 10 | 615803 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR010655 | Pre-mRNA cleavage complex subunit Clp1, C-terminal |
| Domain | IPR032319 | Polyribonucleotide 5'-hydroxyl-kinase Clp1, P-loop domain |
| Domain | IPR032324 | Clp1, N-terminal beta-sandwich domain |
| Family | IPR028606 | Polyribonucleotide 5-hydroxyl-kinase Clp1 |
| Family | IPR045116 | Polyribonucleotide 5-hydroxyl-kinase Clp1/Grc3 |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR038238 | Clp1, C-terminal domain superfamily |
| Homologous_superfamily | IPR038239 | Clp1, N-terminal beta-sandwich domain superfamily |
Domain Details Per Protein
| Protein | Length | Clp1, C-terminal domain superfamily | Clp1, N-terminal beta-sandwich domain | Clp1, N-terminal beta-sandwich domain superfamily | P-loop containing nucleoside triphosphate hydrolase | Polyribonucleotide 5-hydroxyl-kinase Clp1 | Polyribonucleotide 5-hydroxyl-kinase Clp1/Grc3 | Polyribonucleotide 5'-hydroxyl-kinase Clp1, P-loop domain | Pre-mRNA cleavage complex subunit Clp1, C-terminal |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:E7F3I6
|
Interactions and Pathways
No data available
Plasmids
No data available