Gene
gpd2
- ID
- ZDB-GENE-030131-4869
- Name
- glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
- Symbol
- gpd2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to have calcium ion binding activity and glycerol-3-phosphate dehydrogenase (quinone) activity. Predicted to be involved in glycerol-3-phosphate metabolic process and oxidation-reduction process. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Is expressed in several structures, including adaxial cell; ectoderm; musculature system; pectoral fin bud; and peripheral olfactory organ. Orthologous to human GPD2 (glycerol-3-phosphate dehydrogenase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from Thisse et al., 2001
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb853 (9 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| type 2 diabetes mellitus | Alliance | {Type 2 diabetes mellitus, susceptibility to} | 125853 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR018247 | EF-Hand 1, calcium-binding site |
| Domain | IPR002048 | EF-hand domain |
| Domain | IPR006076 | FAD dependent oxidoreductase |
| Domain | IPR031656 | Alpha-glycerophosphate oxidase, C-terminal |
| Family | IPR000447 | FAD-dependent glycerol-3-phosphate dehydrogenase |
| Homologous_superfamily | IPR011992 | EF-hand domain pair |
| Homologous_superfamily | IPR036188 | FAD/NAD(P)-binding domain superfamily |
| Homologous_superfamily | IPR038299 | Alpha-glycerophosphate oxidase, C-terminal domain superfamily |
Domain Details Per Protein
| Protein | Length | Alpha-glycerophosphate oxidase, C-terminal | Alpha-glycerophosphate oxidase, C-terminal domain superfamily | EF-Hand 1, calcium-binding site | EF-hand domain | EF-hand domain pair | FAD-dependent glycerol-3-phosphate dehydrogenase | FAD dependent oxidoreductase | FAD/NAD(P)-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q0P3X1
|
536 | ||||||||
|
UniProtKB:F1Q555
|
726 | ||||||||
|
UniProtKB:A0A8M2BDB8
|
729 |
Interactions and Pathways
No data available
Plasmids
No data available