Gene

prom1a

ID

ZDB-GENE-030131-1577

Name

prominin 1a

Symbol

prom1a Nomenclature History

Previous Names

prom1
proml1
fb75c01
wu:fb75c01

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to have cholesterol binding activity. Predicted to localize to several cellular components, including endoplasmic reticulum-Golgi intermediate compartment; microvillus; and prominosome. Human ortholog(s) of this gene implicated in cone-rod dystrophy 12 and retinitis pigmentosa 41. Is expressed in gill; muscle; nervous system; otic vesicle; and pleuroperitoneal region. Orthologous to human PROM1 (prominin 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

13 figures from 5 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With prom1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
cone-rod dystrophy 12	Alliance	Cone-rod dystrophy 12	612657
retinal macular dystrophy 2	Alliance	Macular dystrophy, retinal, 2	608051
retinitis pigmentosa 41	Alliance	Retinitis pigmentosa 41	612095
Stargardt disease	Alliance	Stargardt disease 4	603786

Associated With prom1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR008795	Prominin

Domain Details Per Protein

Protein	Length	Prominin
UniProtKB:A0A8M9PZ24 InterPro	871
UniProtKB:A0A8M9QGA0 InterPro	894
UniProtKB:A0A8M9QKH3 InterPro	879
UniProtKB:A0A8M9QP25 InterPro	855
UniProtKB:A0A8M3AS96 InterPro	879
UniProtKB:Q9W735 InterPro	826
UniProtKB:A0A8M9QGA5 InterPro	860
UniProtKB:A0A8M3AI42 InterPro	896
UniProtKB:A0A0R4IAM7 InterPro	862
UniProtKB:A0A8M9QP21 InterPro	893
UniProtKB:A0A0R4IE66 InterPro	856
UniProtKB:A0A8M9QAU9 InterPro	902
UniProtKB:A0A0R4IHU7 InterPro	849
UniProtKB:H7BWW9 InterPro	841

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	prom1a-204 (1) Ensembl	Havana	3051 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
aberrant processed transcript	prom1a-208 (1) Ensembl	Havana	3069 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	prom1a-201 (1) Ensembl	Havana	5946 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	prom1a-202 (1) Ensembl	Havana	2948 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	prom1a-206 (1) Ensembl	Havana	2972 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	prom1a-002 (1) Ensembl	Havana	516 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	prom1a-004 (1) Ensembl	Havana	2670 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-prom1a	polyclonal	prom1a		Rabbit			1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations