Gene
nars1
- ID
- ZDB-GENE-030131-1016
- Name
- asparaginyl-tRNA synthetase 1
- Symbol
- nars1 Nomenclature History
- Previous Names
-
- nars
- fb57a10
- si:dkey-274m14.2
- wu:fb57a10 (1)
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to have ATP binding activity; asparagine-tRNA ligase activity; and nucleic acid binding activity. Predicted to be involved in asparaginyl-tRNA aminoacylation. Orthologous to human NARS1 (asparaginyl-tRNA synthetase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from Giong et al., 2021
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neurodevelopmental disorder with microcephaly, impaired language, and gait abnormalities, autosomal recessive | 619091 | ||
| Neurodevelopmental disorder with microcephaly, impaired language, epilepsy, and gait abnormalities, autosomal dominant | 619092 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004364 | Aminoacyl-tRNA synthetase, class II (D/K/N) |
| Domain | IPR004365 | OB-fold nucleic acid binding domain, AA-tRNA synthetase-type |
| Domain | IPR006195 | Aminoacyl-tRNA synthetase, class II |
| Domain | IPR048952 | Asparagine--tRNA ligase, N-terminal domain |
| Family | IPR002312 | Aspartyl/Asparaginyl-tRNA synthetase, class IIb |
| Family | IPR004522 | Asparagine-tRNA ligase |
| Homologous_superfamily | IPR012340 | Nucleic acid-binding, OB-fold |
| Homologous_superfamily | IPR045864 | Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) |
Domain Details Per Protein
| Protein | Length | Aminoacyl-tRNA synthetase, class II | Aminoacyl-tRNA synthetase, class II (D/K/N) | Asparagine-tRNA ligase | Asparagine--tRNA ligase, N-terminal domain | Aspartyl/Asparaginyl-tRNA synthetase, class IIb | Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) | Nucleic acid-binding, OB-fold | OB-fold nucleic acid binding domain, AA-tRNA synthetase-type |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8N7TDX3
|
603 |
Interactions and Pathways
No data available
Plasmids
No data available