Gene

dag1

ID

ZDB-GENE-021223-1

Name

dystroglycan 1

Symbol

dag1 Nomenclature History

Previous Names

dag
dystrophin-associated glycoprotein 1
wu:fb83d06
wu:fi25f06
wu:fi37b08
zgc:109786

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Exhibits laminin binding activity. Involved in several processes, including T-tubule organization; skeletal muscle organ development; and somatic muscle development. Localizes to sarcolemma. Used to study muscular dystrophy-dystroglycanopathy. Human ortholog(s) of this gene implicated in Duchenne muscular dystrophy; autosomal recessive limb-girdle muscular dystrophy type 2D; autosomal recessive limb-girdle muscular dystrophy type 2P; congenital muscular dystrophy-dystroglycanopathy type A9; and inclusion body myositis. Is expressed in several structures, including mesoderm; nervous system; pronephros; somite; and trunk musculature. Orthologous to human DAG1 (dystroglycan 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

51 figures from 26 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

eu576 (13 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 32 figures from 14 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dag1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive limb-girdle muscular dystrophy type 2P	Alliance	Muscular dystrophy-dystroglycanopathy (limb-girdle), type C, 9	613818
congenital muscular dystrophy-dystroglycanopathy type A9	Alliance	Muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 9	616538

Associated With dag1 Via Experimental Models

Human Disease	Fish	Conditions	Citations
muscular dystrophy-dystroglycanopathy type B1	WT + MO1-dag1	standard conditions	Goody et al., 2012

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR006644	Dystroglycan-type cadherin-like
Domain	IPR008465	Dystroglycan, C-terminal
Domain	IPR030398	DG-type SEA domain
Domain	IPR041631	Alpha-dystroglycan N-terminal domain 2
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR015919	Cadherin-like superfamily
Homologous_superfamily	IPR027468	Alpha-dystroglycan domain 2

Domain Details Per Protein

Protein	Length	Alpha-dystroglycan domain 2	Alpha-dystroglycan N-terminal domain 2	Cadherin-like superfamily	DG-type SEA domain	Dystroglycan, C-terminal	Dystroglycan-type cadherin-like	Immunoglobulin-like fold
UniProtKB:Q8JHU7 InterPro	866
UniProtKB:F1QMH7 InterPro	866

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	dag1-201 (1) Ensembl	Havana	3596 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	dag1-202 (1) Ensembl	Havana	5674 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-dag1	monoclonal	dag1	IgM	Mouse	IHC WB	Santa Cruz Biotechnology, Inc. Millipore	17
Ab5-dag1	polyclonal	dag1		Rabbit	WB		2
Ab3-dag1	monoclonal	dag1	IgG2a	Mouse	IHC WB	Leica Microsystems Inc. Abcam plc	29
Ab2-dag1	monoclonal	dag1	IgG1	Mouse	IHC WB	Millipore	5
Ab4-dag1	monoclonal	dag1	IgG1 , l	Mouse	IHC WB	Developmental Studies Hybridoma Bank	7

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations