Gene

cdon

ID

ZDB-GENE-021115-4

Name

cell adhesion associated, oncogene regulated

Symbol

cdon Nomenclature History

Previous Names

cb507 (1)
wu:fa10c03
wu:fb94b11
zgc:158240

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Involved in negative regulation of smoothened signaling pathway. Predicted to localize to integral component of plasma membrane. Human ortholog(s) of this gene implicated in holoprosencephaly 11. Is expressed in several structures, including immature eye; mesoderm; nervous system; neural tube; and pectoral fin. Orthologous to human CDON (cell adhesion associated, oncogene regulated).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

15 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

cb507 (31 images)
IMAGE:7156053 (15 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Cardozo et al., 2014
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cdon Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
holoprosencephaly 11	Alliance	Holoprosencephaly 11	614226

Associated With cdon Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003598	Immunoglobulin subtype 2
Domain	IPR003599	Immunoglobulin subtype
Domain	IPR003961	Fibronectin type III
Domain	IPR007110	Immunoglobulin-like domain
Domain	IPR013098	Immunoglobulin I-set
Domain	IPR013106	Immunoglobulin V-set domain
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036116	Fibronectin type III superfamily
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily

Domain Details Per Protein

Protein	Length	Fibronectin type III	Fibronectin type III superfamily	Immunoglobulin I-set	Immunoglobulin-like domain	Immunoglobulin-like domain superfamily	Immunoglobulin-like fold	Immunoglobulin subtype	Immunoglobulin subtype 2	Immunoglobulin V-set domain
UniProtKB:Q1L8D0 InterPro	1125

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	cdon-201 (1) Ensembl	Havana	4143 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	cdon-002 (1) Ensembl	Havana	843 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations