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General Information
ZIRC
ZFIN ID: ZDB-GENE-011119-1
Gene Name: glypican 4
Gene Symbol: gpc4
GO Details
Ontology Qualifier Term Evidence Inferred From Annotation Extension Reference(s)
Molecular Function protein binding IPI UniProtKB:Q9W6D9 Caneparo et al., 2007
Cellular Component anchored component of membrane IEA UniProtKB-KW:KW-0336 ZFIN Electronic Annotation
anchored component of plasma membrane IEA InterPro:IPR001863 ZFIN Electronic Annotation
cell surface IBA PANTHER:PTN002247069, WB:WBGene00003056, FB:FBgn0041604, FB:FBgn0263930, UniProtKB:O75487 Gaudet et al., 2010
collagen-containing extracellular matrix IEA InterPro:IPR001863 ZFIN Electronic Annotation
extracellular region IBA PANTHER:PTN002247069, MGI:MGI:1194891 Gaudet et al., 2010
membrane IEA UniProtKB-KW:KW-0472 ZFIN Electronic Annotation
synapse IBA MGI:MGI:1346322, PANTHER:PTN000088172, MGI:MGI:1194891, FB:FBgn0041604, MGI:MGI:104902, RGD:1593308, RGD:1359399 Gaudet et al., 2010
Biological Process cartilage development IMP gpc4m119/m119 Wiweger et al., 2011
cartilage morphogenesis IMP gpc4hi1688Tg/hi1688Tg Ling et al., 2017
cartilage morphogenesis IMP gpc4m818/m818 Sisson et al., 2015
cartilage morphogenesis IMP gpc4fr6/fr6 Sisson et al., 2015
cell migration IBA UniProtKB:Q9Y625, PANTHER:PTN002247069, FB:FBgn0041604, FB:FBgn0263930, WB:WBGene00001687 Gaudet et al., 2010
cell migration IGI gpc4, mmp14b occurs_in(endodermal cell) Hu et al., 2018
cell migration IGI mmp14a, gpc4 occurs_in(endodermal cell) Hu et al., 2018
cell migration IGI mmp14a, mmp14b occurs_in(endodermal cell) Hu et al., 2018
cell migration IMP MO2-mmp14b, MO4-mmp14a occurs_in(endodermal cell) Hu et al., 2018
cell migration IMP gpc4fr6/fr6 occurs_in(endodermal cell) Hu et al., 2018
cell migration involved in gastrulation IGI dkk1b Caneparo et al., 2007
convergent extension IMP MO2-gpc4 Shao et al., 2009
convergent extension IMP gpc4m119/m119; vangl2m209/m209 Yin et al., 2008
convergent extension involved in axis elongation IGI gpc4m119/m119; tbxtab195/b195 Marlow et al., 2004
convergent extension involved in axis elongation IMP MO2-gpc4 Shao et al., 2009
convergent extension involved in gastrulation IGI vangl2, gpc4m119/m119; vangl2m209/m209 Yin et al., 2007
convergent extension involved in gastrulation IGI MO1-gpc4 Young et al., 2014
convergent extension involved in gastrulation IGI gpc4m119/m119 , MO2-mmp14b, MO4-mmp14a Coyle et al., 2008
convergent extension involved in gastrulation IGI gpc4m119/m119; wnt11f2tz216/tz216 Topczewski et al., 2001
convergent extension involved in gastrulation IMP MO2-gpc4 Shao et al., 2009
convergent extension involved in gastrulation IMP gpc4m119/m119 Coyle et al., 2008
convergent extension involved in gastrulation IMP gpc4m119/+ Coyle et al., 2008
dorsal convergence IMP gpc4m119/m119 (AB) Stemple et al., 1996
endochondral ossification IMP gpc4hi1688Tg/hi1688Tg Ling et al., 2017
establishment of cell polarity involved in gastrulation cell migration IMP gpc4m119/m119 (AB) Topczewski et al., 2001
extracellular matrix organization IMP gpc4m119/m119 2 Publications
gastrulation with mouth forming second IMP gpc4m119/m119 (AB) Lin et al., 2005
lamellipodium organization IGI mmp14a, mmp14b part_of(endodermal cell) Hu et al., 2018
lamellipodium organization IMP gpc4fr6/fr6 part_of(endodermal cell) Hu et al., 2018
muscle cell development IMP gpc4fr6/fr6 Venero Galanternik M. et al., 2016
muscle cell migration IGI gpc4m119/m119; vangl2m209/m209 Yin et al., 2007
muscle cell migration IMP gpc4m119/m119 Yin et al., 2007
notochord development IMP gpc4m119/m119 (AB) Stemple et al., 1996
ossification IMP gpc4hi1688Tg/hi1688Tg Ling et al., 2017
post-anal tail morphogenesis IGI tll1tc263a/tc263a , gpc4fr6/fr6 Yang et al., 2011
post-anal tail morphogenesis IMP gpc4fr6/fr6 Yang et al., 2011
protein localization IGI dkk1b Caneparo et al., 2007
proteoglycan biosynthetic process IMP gpc4m119/m119 Wiweger et al., 2011
regulation of cell migration IGI dkk1b Caneparo et al., 2007
regulation of extracellular matrix assembly IGI mmp14a, mmp14b Hu et al., 2018
regulation of extracellular matrix assembly IMP gpc4fr6/fr6 Hu et al., 2018
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IBA PANTHER:PTN002585530, RGD:1593308, RGD:1359399 Gaudet et al., 2010
regulation of presynapse assembly IBA PANTHER:PTN002585530, RGD:1359399 Gaudet et al., 2010
regulation of protein localization to membrane IBA PANTHER:PTN002247069, RGD:1593308, RGD:1359399 Gaudet et al., 2010
regulation of signal transduction IEA InterPro:IPR001863 ZFIN Electronic Annotation
striated muscle cell development IGI gpc4m119/m119; vangl2m209/m209 Yin et al., 2007
striated muscle cell development IMP gpc4m119/m119 Yin et al., 2007
synaptic membrane adhesion IBA PANTHER:PTN002585530, MGI:MGI:104902 Gaudet et al., 2010
unidimensional cell growth IMP gpc4m119/m119 (AB) Lin et al., 2005