Gene
ugdh
- ID
- ZDB-GENE-011022-1
- Name
- UDP-glucose 6-dehydrogenase
- Symbol
- ugdh Nomenclature History
- Previous Names
-
- ik:tdsubc_2a8 (1)
- jek
- jekyll
- sb:eu659
- tdsubc_2a8
- xx:tdsubc_2a8
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to have NAD binding activity and UDP-glucose 6-dehydrogenase activity. Involved in atrioventricular valve formation; determination of left/right symmetry; and positive regulation of signal transduction. Predicted to localize to cytosol and nucleus. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy. Is expressed in several structures, including axis; head; heart tube; mesoderm; and vestibuloauditory system. Orthologous to human UGDH (UDP-glucose 6-dehydrogenase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu659 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- 23 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| developmental and epileptic encephalopathy 84 | Alliance | Developmental and epileptic encephalopathy 84 | 618792 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001732 | UDP-glucose/GDP-mannose dehydrogenase, N-terminal |
| Domain | IPR014026 | UDP-glucose/GDP-mannose dehydrogenase, dimerisation |
| Domain | IPR014027 | UDP-glucose/GDP-mannose dehydrogenase, C-terminal |
| Family | IPR017476 | UDP-glucose/GDP-mannose dehydrogenase |
| Family | IPR028356 | UDP-glucose 6-dehydrogenase, eukaryotic type |
| Homologous_superfamily | IPR008927 | 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily |
| Homologous_superfamily | IPR036220 | UDP-glucose/GDP-mannose dehydrogenase, C-terminal domain superfamily |
| Homologous_superfamily | IPR036291 | NAD(P)-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily | NAD(P)-binding domain superfamily | UDP-glucose 6-dehydrogenase, eukaryotic type | UDP-glucose/GDP-mannose dehydrogenase | UDP-glucose/GDP-mannose dehydrogenase, C-terminal | UDP-glucose/GDP-mannose dehydrogenase, C-terminal domain superfamily | UDP-glucose/GDP-mannose dehydrogenase, dimerisation | UDP-glucose/GDP-mannose dehydrogenase, N-terminal |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A8WGP7
|
493 |
Interactions and Pathways
No data available
Plasmids
No data available