Gene

fh

ID

ZDB-GENE-010724-6

Name

fumarate hydratase

Symbol

fh Nomenclature History

Previous Names

im:7152785
ns:zf-e152
zf-e152
zgc:66253
zgc:77498

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to have fumarate hydratase activity. Predicted to be involved in fumarate metabolic process; malate metabolic process; and tricarboxylic acid cycle. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in fumarase deficiency. Is expressed in several structures, including adaxial cell; alar plate midbrain region; immature eye; liver; and optic tectum. Orthologous to human FH (fumarate hydratase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

IMAGE:7152785 (11 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Hwang et al., 2013
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fh Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
fumarase deficiency	Alliance	Fumarase deficiency	606812
		Leiomyomatosis and renal cell cancer	150800

Associated With fh Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020557	Fumarate lyase, conserved site
Domain	IPR018951	Fumarase C, C-terminal
Domain	IPR022761	Fumarate lyase, N-terminal
Family	IPR000362	Fumarate lyase family
Family	IPR005677	Fumarate hydratase, class II
Homologous_superfamily	IPR008948	L-Aspartase-like
Homologous_superfamily	IPR024083	Fumarase/histidase, N-terminal