Gene
mafaa
- ID
- ZDB-GENE-010605-3
- Name
- MAF bZIP transcription factor Aa
- Symbol
- mafaa Nomenclature History
- Previous Names
-
- mafa
- mafl
- SMaf1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Exhibits sequence-specific DNA binding activity. Predicted to be involved in multicellular organism development and regulation of transcription, DNA-templated. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Is expressed in myotome; nervous system; neural tube; and somite. Orthologous to human MAFA (MAF bZIP transcription factor A).
- Genome Resources
- Note
-
This gene, the ortholog of the human MAFA gene, does not appear to have a genome duplicate. It was assigned the 'a' genome duplicate nomenclature to allow accommodation of zebrafish gene symbols mafa and mafb for the orthologs (and genome duplicates) of human MAF.
- Comparative Information
-
- All Expression Data
- 6 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:6911585 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Insulinomatosis and diabetes mellitus | 147630 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004826 | Basic leucine zipper domain, Maf-type |
| Domain | IPR004827 | Basic-leucine zipper domain |
| Domain | IPR013592 | Maf transcription factor, N-terminal |
| Family | IPR024874 | Transcription factor Maf family |
| Homologous_superfamily | IPR008917 | Transcription factor, Skn-1-like, DNA-binding domain superfamily |
| Homologous_superfamily | IPR046347 | Basic-leucine zipper domain superfamily |
Domain Details Per Protein
| Protein | Length | Basic-leucine zipper domain | Basic leucine zipper domain, Maf-type | Basic-leucine zipper domain superfamily | Maf transcription factor, N-terminal | Transcription factor Maf family | Transcription factor, Skn-1-like, DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:B3DGB3
|
315 | ||||||
|
UniProtKB:A3KMR8
|
315 |
Interactions and Pathways
No data available
Plasmids
No data available