Gene

cd74a

ID

ZDB-GENE-000901-1

Name

CD74 molecule, major histocompatibility complex, class II invariant chain a

Symbol

cd74a Nomenclature History

Previous Names

Iclp-1
iclp1
MHC II (1)
wu:fb11f09 (1)
wu:fb12a01 (1)
wu:fb13d06 (1)
wu:fk94e07 (1)

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to have MHC class II protein binding activity. Involved in T cell activation involved in immune response; dendritic cell antigen processing and presentation; and sensory organ development. Localizes to cell surface. Is expressed in dendritic cell; otic vesicle; pectoral fin bud; pharyngeal arch; and sensory system. Orthologous to human CD74 (CD74 molecule).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

15 figures from 7 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:77643 (2 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cd74a Human Ortholog

No data available

Associated With cd74a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000716	Thyroglobulin type-1
Domain	IPR015386	MHC class II-associated invariant chain/CLIP, MHC II-interacting
Family	IPR043530	HLA class II histocompatibility antigen, gamma subunit
Homologous_superfamily	IPR036857	Thyroglobulin type-1 superfamily

Domain Details Per Protein

Protein	Length	HLA class II histocompatibility antigen, gamma subunit	MHC class II-associated invariant chain/CLIP, MHC II-interacting	Thyroglobulin type-1	Thyroglobulin type-1 superfamily
UniProtKB:Q9PUT2 InterPro	237

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	cd74a-202 (1) Ensembl	Havana	534 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	cd74a-201 (1) Ensembl	Havana	1273 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	cd74a-203 (1) Ensembl	Havana	840 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-cd74a		cd74a	IgG	Rabbit	IHC		3

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations