UniProt ID: Q9PWC7 |
FUNCTION: Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation. {ECO:0000256|RuleBase:RU367066}. SUBCELLULAR LOCATION: Zona pellucida {ECO:0000256|RuleBase:RU367066}. Cell membrane {ECO:0000256|RuleBase:RU367066}; Single-pass type I membrane protein {ECO:0000256|RuleBase:RU367066}. DOMAIN: The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida. {ECO:0000256|RuleBase:RU367066}. PTM: Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida. {ECO:0000256|RuleBase:RU367066}. SIMILARITY: Belongs to the ZP domain family. ZPC subfamily. {ECO:0000256|RuleBase:RU367066}. |
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