UniProt ID: Q9I8V2 |
FUNCTION: Involved in ventralization. May mediate Bmp2b signaling during embryonic dorsal-ventral pattern formation, and may itself be a transcriptional target for Smad5-mediated Bmp2b signaling. {ECO:0000269|PubMed:10525190, ECO:0000269|PubMed:10590480}. SUBUNIT: May form trimers with another Smad1 and the co-Smad Smad4. {ECO:0000250}. SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q15797}. Nucleus {ECO:0000250|UniProtKB:Q15797}. Note=In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with Smad4. {ECO:0000250|UniProtKB:Q15797}. DEVELOPMENTAL STAGE: Zygotically expressed. First detected 1 h after the midblastula transition. During gastrulation, expression is restricted to ventral regions. Later, expressed in the somites, eyes and a subset of dorsal cells in the hindbrain. Levels increase until the end of gastrulation and then remain high. {ECO:0000269|PubMed:10525190, ECO:0000269|PubMed:10590480}. SIMILARITY: Belongs to the dwarfin/SMAD family. {ECO:0000305}. |
UniProt ID: Q5PQZ2 |
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU361195}. Nucleus {ECO:0000256|RuleBase:RU361195}. SIMILARITY: Belongs to the dwarfin/SMAD family. {ECO:0000256|ARBA:ARBA00005545, ECO:0000256|RuleBase:RU361195}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |