UniProt ID: Q800Q5 |
FUNCTION: Participates in the Wnt signaling pathway. Probably binds to DNA and acts as a repressor in the absence of ctnnb1, and possibly as an activator in its presence. Regulates anterior-posterior patterning in the neuroectoderm by repressing posterior neural fates. Also required for hindbrain morphogenesis. {ECO:0000269|PubMed:12642497, ECO:0000269|PubMed:15151990, ECO:0000269|PubMed:15366005, ECO:0000269|PubMed:15659486}. SUBUNIT: Interacts with ctnnb1. {ECO:0000250}. SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}. DEVELOPMENTAL STAGE: Expressed maternally and throughout embryogenesis. Expressed in the rostral neuroectoderm and at low levels in the notochord following gastrulation. Expressed throughout the developing brain during somitogenesis. {ECO:0000269|PubMed:12642497}. SIMILARITY: Belongs to the TCF/LEF family. {ECO:0000305}. |
UniProt ID: F1R336 |
SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}. SIMILARITY: Belongs to the TCF/LEF family. {ECO:0000256|ARBA:ARBA00006569}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |