UniProt ID: Q7SZS1 |
FUNCTION: May function as a switch in neuronal development (By similarity). Acts as a negative regulator of transcription. Plays a role in dorsoventral patterning of the embryo. {ECO:0000250|UniProtKB:Q9W7R5, ECO:0000269|PubMed:15037315}. SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}. TISSUE SPECIFICITY: Expressed in all cells until gastrulation, becoming restricted to the developing central nervous system later, where expression is in the forebrain, midbrain and hindbrain but maximally at the midbrain-hindbrain boundary. {ECO:0000269|PubMed:10370117, ECO:0000269|PubMed:10559493}. DEVELOPMENTAL STAGE: Expressed both maternally and zygotically. Expressed in oocytes and throughout embryogenesis, whereas expression in adults is undetectable. {ECO:0000269|PubMed:10559493, ECO:0000269|PubMed:15037315}. DISRUPTION PHENOTYPE: Ventralized embryos. {ECO:0000269|PubMed:15037315}. |
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