UniProt ID: Q9W6H5 |
FUNCTION: Accepts the ubiquitin-like proteins sumo1, sumo2 and sumo3 from the uble1a-uble1b E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as ranbp2 or cbx4. Essential for nuclear architecture and chromosome segregation (By similarity). Mediates nuclear localization of vsx1. Required for progression through mitosis during organogenesis. {ECO:0000250, ECO:0000269|PubMed:11331779, ECO:0000269|PubMed:17035631}. PATHWAY: Protein modification; protein sumoylation. SUBUNIT: Forms a tight complex with rangap1 and ranbp2 (By similarity). Interacts with vsx1. {ECO:0000250, ECO:0000269|PubMed:11331779}. SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family. {ECO:0000255|PROSITE-ProRule:PRU00388}. |
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