UniProt ID: Q90462 |
FUNCTION: This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. {ECO:0000256|ARBA:ARBA00025215, ECO:0000256|RuleBase:RU368113}. SUBUNIT: Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence. {ECO:0000256|RuleBase:RU368113}. SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU368113}; Peripheral membrane protein {ECO:0000256|RuleBase:RU368113}; Cytoplasmic side {ECO:0000256|RuleBase:RU368113}. Cell projection, growth cone membrane {ECO:0000256|ARBA:ARBA00004503, ECO:0000256|RuleBase:RU368113}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004503, ECO:0000256|RuleBase:RU368113}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004503, ECO:0000256|RuleBase:RU368113}. Synapse {ECO:0000256|ARBA:ARBA00034103, ECO:0000256|RuleBase:RU368113}. Cell projection, filopodium membrane {ECO:0000256|RuleBase:RU368113}; Peripheral membrane protein {ECO:0000256|RuleBase:RU368113}. Membrane {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004287}. PTM: Palmitoylated. Palmitoylation is essential for plasma membrane association. {ECO:0000256|RuleBase:RU368113}. SIMILARITY: Belongs to the neuromodulin family. {ECO:0000256|ARBA:ARBA00005890, ECO:0000256|RuleBase:RU368113}. |
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