UniProt ID: O57341 |
FUNCTION: Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis (PubMed:19164561). {ECO:0000250|UniProtKB:P55075, ECO:0000269|PubMed:19164561}. SUBUNIT: Monomer (By similarity). Homodimer (By similarity). {ECO:0000250|UniProtKB:P55075}. SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P55075}. DEVELOPMENTAL STAGE: Expressed in Kupffer's vesicle. {ECO:0000269|PubMed:19164561}. DISRUPTION PHENOTYPE: Morpholino knockdown of the protein causes a dramatic loss of cilia in Kupffer's vesicle. {ECO:0000269|PubMed:19164561}. SIMILARITY: Belongs to the heparin-binding growth factors family. {ECO:0000255|RuleBase:RU049442}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |