UniProt ID: B0CLY3 |
SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single- pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}. SIMILARITY: Belongs to the ephrin family. {ECO:0000256|PROSITE- ProRule:PRU00884, ECO:0000256|RuleBase:RU004375}. CAUTION: Lacks conserved residue(s) required for the propagation of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00884}. |
UniProt ID: O73874 |
FUNCTION: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with ephb4 may play a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration (By similarity). {ECO:0000250}. SUBUNIT: Binds to the receptor tyrosine kinase ephb4. SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P52799}; Single-pass type I membrane protein {ECO:0000255}. PTM: Inducible phosphorylation of tyrosine residues in the cytoplasmic domain. {ECO:0000250}. SIMILARITY: Belongs to the ephrin family. {ECO:0000255|PROSITE- ProRule:PRU00884}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |