UniProt ID: Q1LV36
SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000256|RuleBase:RU000461}.
UniProt ID: Q9DG53
SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000256|RuleBase:RU000461}.
UniProt ID: Q98UC7
SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000256|RuleBase:RU000461}.
UniProt ID: A0A2R8Q9I0
SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000256|RuleBase:RU000461}.
UniProt ID: O42145
FUNCTION: Catalyzes the formation of aromatic C18 estrogens from C19 androgens. {ECO:0000250}.
CATALYTIC ACTIVITY: Reaction=3 O2 + 3 reduced [NADPH--hemoprotein reductase] + testosterone = 17beta-estradiol + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:38191, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:15740, ChEBI:CHEBI:16469, ChEBI:CHEBI:17347, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; EC=1.14.14.14; Evidence={ECO:0000250|UniProtKB:P11511};
CATALYTIC ACTIVITY: Reaction=androst-4-ene-3,17-dione + 3 O2 + 3 reduced [NADPH-- hemoprotein reductase] = estrone + formate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:38195, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:15740, ChEBI:CHEBI:16422, ChEBI:CHEBI:17263, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; EC=1.14.14.14; Evidence={ECO:0000250|UniProtKB:P11511};
COFACTOR: Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein.
SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
UniProt ID: Q9DG54
SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000256|RuleBase:RU000461}.
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