UniProt ID: F1QKY4 |
SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}. SIMILARITY: Belongs to the chordin family. {ECO:0000256|ARBA:ARBA00007156, ECO:0000256|PIRNR:PIRNR002496}. |
UniProt ID: O57472 |
FUNCTION: Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity). {ECO:0000250, ECO:0000269|PubMed:9441687}. SUBUNIT: Interacts with twsg1 and/or bmp4. {ECO:0000250}. SUBCELLULAR LOCATION: Secreted {ECO:0000250}. TISSUE SPECIFICITY: During gastrulation, levels are highest in the organizer region. Also present in the developing brain and in paraxial mesoderm and ectoderm. {ECO:0000269|PubMed:9441687}. DEVELOPMENTAL STAGE: First detected shortly after the midbastula transition. Levels increase during gastrulation, persist through early somatogenesis, but then decrease and are gone by 24 hours. {ECO:0000269|PubMed:9441687}. PTM: Cleaved by tolloid proteases; cleavage participates in dorsoventral patterning during early development. {ECO:0000250}. SIMILARITY: Belongs to the chordin family. {ECO:0000305}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |